We take an inside look into what laser capture microdissection is and how it is enabling scientists at the Wellcome Sanger Institute to precisely isolate cells and reveal detailed insights into biology and disease.

From invasive mussels to sloths, Dr Marcela Uliano da Silva at the Wellcome Sanger Institute shares her varied career journey, with a consistent focus on inclusive research and effective scientific communication.

Navigating unexpected turns, discovering her passion and striving for work with real-world impact – reflections from Vanessa Burns, PhD student at the Wellcome Sanger Institute.

From bacterial defence to breakthrough therapies, we explore how CRISPR-Cas is transforming research and healthcare, and how experts at the Wellcome Sanger Institute are refining the technology to make genome editing more scalable and effective.

Changes in the PTEN gene, that causes PTEN hamartoma tumour syndrome (PHTS), can lead to a range of different manifestations that vary from person to person, including an increased risk of certain cancers. A new project aims to understand why some tissues in people with PHTS become cancerous, and if there is a way of identifying individuals with PTEN variants who are most at risk.