From bacterial defence to breakthrough therapies, we explore how CRISPR-Cas is transforming research and healthcare, and how experts at the Wellcome Sanger Institute are refining the technology to make genome editing more scalable and effective.
Changes in the PTEN gene, that causes PTEN hamartoma tumour syndrome (PHTS), can lead to a range of different manifestations that vary from person to person, including an increased risk of certain cancers. A new project aims to understand why some tissues in people with PHTS become cancerous, and if there is a way of identifying individuals with PTEN variants who are most at risk.
Small flies, big mysteries. Genomics can help reveal the evolutionary picture of these two-winged wonders.
From aspiring dentist to sequencing specialist, Ashleigh Williams, Advanced Research Assistant at the Wellcome Sanger Institute shares how following her curiosity led to a career full of cutting-edge technologies and unexpected turns.
Sanger Science
Sanger Life
Innovation
26 May 2026In the latest installment of our innovator blog series, we caught up with Dr Matthew Coelho, Cancer Research UK Career Development Fellow at the Wellcome Sanger Institute. Matthew works within the Somatic Genomics programme and is co-founder of BASE Rx alongside Group Leader, Dr Mathew Garnett.
